Alprazolam may slow or stop your breathing, especially if you have recently taken an opioid medication, drank alcohol, or taken other drugs that slow your breathing.


The following medicines that may increase the effects of Xanax:


    • nefazodone
    • ketoconazole (Nizoral)
    • fluvoxamine (Luvox)
  • cimetidine (Tagamet)
  • erythromycin (Erythrocin)
  • HIV protease inhibitors, such as ritonavir (Norvir)


Taking benzodiazepines such as Xanax with certain drugs can produce different depressant effects on the CNS. These drugs include:


    • anticonvulsants


Other medications that could interact with Xanax include:


    • fluoxetine (Prozac)
    • imipramine (Tofranil) and desipramine (Norpramin)
  • propoxyphene (Darvon)
  • digoxin (Lanoxin), in people above 65 years 


Benzodiazepines other than Xanax may interact with the following drugs:


    • some antibiotics
    • diltiazem (Cardizem)
    • isoniazid (Hydra)
    • grapefruit juice
    • sertraline (Zoloft)
    • some heart or blood pressure medications
    • ergotamine (Cafergot, Ergomar, Migergot)
    • cyclosporine (Gengraf, Neoral, Sandimmune)
  • dexamethasone (Cortastat, Dexasone, Solurex, DexPak)
  • imatinib (Gleevec)
  • some barbiturates
  • antifungal drugs, such as miconazole (Oravig) or voriconazole (Vfend)
  • antidepressants, such as nefazodone or fluoxetine (Prozac) 
  • some seizure medications
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